beREADY - endometrial receptivity test
Benefits of endometrial receptivity testing
70% of patients gave birth after first year of IVF treatment using endometrial receptivity test**
72.4% pregnancy rate was acheived by first IVF cycle when endometrial receptivity test was used**
Have you experienced IVF failure?
Did you know that 1 out of 3 patient experience IVF failure because the embryo is transferred too early or too late****
What does personalised medicine mean in IVF?
What does the beREADY test show?
The test measures the maturity level of your endometrium and enables your fertility doctor to perform the embryo transfer on the right day in the IVF cycle. The results are reported in three main categories with possible chances:
PRE or EARLY-RECEPTIVE
Embryo transfer should be done later in the IVF cycle
Embryo transfer can be done using the same treatment plan
LATE or POST-RECEPTIVE
Embryo transfer should be done earlier in the IVF cycle
How does the beREADY test work?
Results in 1-2 weeks
beREADY comparison with ERA test
The beREADY test has been validated under clinical conditions in IVF clinics to demonstrate the test’s accuracy. In total, 45 HRT patients’ samples were involved in a comparison against the Endometrial Receptivity Analysis (ERA, Igenomix) test. The concordance rate between two tests is 96%.
The small difference is due to the difference in testing methods. The beREADY applies a highly accurate TAC-seq DNA sequencing technology that enables beREADY to detect bio-marker molecules at a single molecule level, providing ultimate accuracy.
beREADY test uses unique patented TAC-seq sequencing technology that ensures ultimate accuracy. The original data analysis algorithm is published* and adjusted to diagnostic assay.
Referred publications and research behind beREADY test
* Teder et al., TAC-seq: targeted DNA and RNA sequencing for precise biomarker molecule counting. 2018, npj Genomic Medicine, PubMed ID 30588329 Link to original study
** Simón et al. A 5-year Multicenter Randomized Controlled Trial of In Vitro Fertilization with Personalized Blastocyst Transfer versus Frozen or Fresh Transfer. 2020, Reproductive BioMedicine Online, PubMed ID 32723696. Link to original study
*** Haouzi et al. Customized Frozen Embryo Transfer after Identification of the Receptivity Window with a Transcriptomic Approach Improves the Implantation and Live Birth Rates in Patients with Repeated Implantation Failure. 2021, Reproductive Sciences, PubMed ID 32725589. Link to original study
**** Ruiz-Alonso et al., The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure. 2013, Fertility and Sterility, PubMed ID 23756099. Link to original study
Saare et al., A molecular tool for menstrual cycle phase dating in endometriosis transcriptomic studies. 2019, Biology of Reproduction, PubMed ID 31004479 Link to original study
Suhorutshenko et al., Endometrial receptivity revisited: endometrial transcriptome adjusted for tissue cellular heterogeneity. 2018, Human Reproduction, PubMed ID 30295736 Link to original study
Altmäe et al., Meta-signature of human endometrial receptivity: a meta-analysis and validation study of transcriptomic biomarkers. 2018, Scientific Reports, PubMed ID 28855728 Link to original study
Krjutškov et al., Single-cell transcriptome analysis of endometrial tissue. 2016, Human Reproduction, PubMed ID 26874359 Link to original study